منابع مشابه
Use of N-acetylcysteine for postnecrosectomy peripancreatic collections in a patient with severe, acute pancreatitis.
the management of various medical conditions such as chronic bronchitis and acetaminophen poisoning, and in tracheostomy care. We report its use as a mucolytic agent in the treatment of peripancreatic collections after necrosectomy for acute pancreatitis, and its effect on patient recovery. van Waes and colleagues in 1983 demonstrated the efficacy of NAC in breaking down the viscosity of drain ...
متن کاملN-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis
BACKGROUND/AIMS To investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP). METHODS Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group. The ANP model was established by a retrograde injection of 3% sodium taurocholate into the pancreatic duct. The NAC-treated group received ...
متن کاملEvaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteine
Background: Acetaminophen (N-Acetyl-p aminophenol; APAP) is one of the most common types of analgesics. It is also the most common xneobitic reported to poison centers. This study investigates if therapeutic doses of NAC can falsely increase coagulation tests, prothrombin time (PT) and bleeding time (BT). Methods: Thirty-six APAP poisoned patients whose acetaminophen serum concentration were...
متن کاملAcute and Chronic Effects of N-acetylcysteine on Pentylenetetrazole-induced Seizure and Neuromuscular Coordination in Mice
Background: N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses.Methods: Following intraperitoneal (i.p.) administration of N...
متن کاملRandomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis.
BACKGROUND Based on equivocal clinical data, intravenous antioxidant therapy has been used for the treatment of severe acute pancreatitis. To date there is no randomised comparison of this therapy in severe acute pancreatitis. METHODS We conducted a randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in patients with pr...
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ژورنال
عنوان ژورنال: World Journal of Gastrointestinal Pharmacology and Therapeutics
سال: 2010
ISSN: 2150-5349
DOI: 10.4292/wjgpt.v1.i1.21